Alexander Fleming: a second look

Authors

DOI:

https://doi.org/10.5195/jmla.2024.1780

Abstract

In 1928, Alexander Fleming (1881-1955) identified penicillin, the world's first antibiotic. It was a chance discovery that could have easily been missed had Fleming not taken a second look at a contaminated Petri dish. The discovery of penicillin marked a profound turning point in history as it was the first time deadly infections such as bacterial pneumonia, sepsis, diphtheria, meningitis, and puerperal fever after childbirth could be cured, and it paved the way for the development of additional antibiotics. The Alexander Fleming Laboratory Museum, one of several London Museums of Health and Medicine, is a reconstruction of Fleming’s laboratory in its original location at St. Mary’s Hospital. As if stepping back in time, visitors gain a glimpse into the man, his bacteriology work, and the events surrounding this important finding. For those unable to travel to London, this article provides a brief narrative of the fascinating story.

References

London museums of health and medicine. 2023 [cited 14 May 2023] http://medicalmuseums.org/.

Brown, K. Penicillin Man: Alexander Fleming and the antibiotic revolution. Stroud, Gloucestershire: Sutton Publishing; 2004.

Chain E. Thirty years of penicillin therapy. Journal of the Royal College of Physicians of London. 1972 Jan;6(2):103-131.

Henderson JW. The yellow brick road to penicillin: a story of serendipity. Mayo Clinic Proceedings. 1997;72(7):683-7. DOI: https://doi.org/10.1016/s0025-6196(11)63577-5.

Wainwright M. Fleming's unfinished. Perspectives in Biology and Medicine. 2002;45(4):529-38.

Allison VD. Personal recollections of Sir Almroth Wright and Sir Alexander Fleming. The Ulster Medical Journal. 1974;43(2):89-98.

Madden JL. Chance only favours the mind which is prepared. Surgery, gynecology & obstetrics. 1973 Mar;136(3):444-5.

Advertisement for penicillin production from Life Magazine. [Internet] Wellcome Collection, London. 1944 [cited 14 May 2023]. https://wellcomecollection.org/works/apnj2urs.

Garrod LP. Alexander Fleming. A dedication on the 50th anniversary of the discovery of penicillin. British Journal of Experimental Pathology. 1979 Feb;60(1):1-2.

Agricultural Research Service. U.S. Department of Agriculture. Penicillin: Opening the era of antibiotics. [Internet] 2018 [cited 14 May 2023]. https://www.ars.usda.gov/midwest-area/peoria-il/national-center-for-agricultural-utilization-research/docs/penicillin-opening-the-era-of-antibiotics/.

Diggins FW. The discovery of penicillin: so many get it wrong. Biologist. 2000;47(3):115-9.

Mailer JS Jr., Mason B. Penicillin: Medicine's wartime wonder drug and its production at Peoria, Illinois. Illinois Periodicals Online [Internet]. Northern Illinois University Libraries. 2001 [cited 14 May 2023]. https://www.lib.niu.edu/2001/iht810139.html.

Sykes R. Penicillin: from discovery to product. Bulletin of the World Health Organization. 2001; 79:778-9.

Quinn R. Rethinking antibiotic research and development: World War II and the penicillin collaborative. American journal of public health. 2013 Mar;103(3):426-34.

Gaynes R. The Discovery of penicillin—New insights after more than 75 years of clinical use. Emerging Infectious Diseases. 2017 May;23(5):849–53. DOI: https://doi.org/10.3201/eid2305.161556.

Oxford Centre for Global History. Penicillin and the antibiotic revolution. [Internet] University of Oxford. 2020 [cited 14 May 2023]. https://globalcapitalism.history.ox.ac.uk/files/case18penicillinv2pdf.

Wainwright, M. Hitler’s penicillin. Perspectives in Biology and Medicine. 2004 47(2): 189-198.

Shama, G, Reinarz, J. Allied intelligence reports on wartime German penicillin research and production. Historical studies in the physical and biological sciences. 2002 32(2): 347-367.

Antimicrobial resistance. [Internet] World Health Organization. 2021 [cited 10 June 2023]. https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance.

Lobanovska, M Pilla, G. Penicillin’s discovery and antibiotic resistance: Lessons for the future? Yale Journal of Biology and Medicine. 2017 90(1): 135-145.

Downloads

Published

2024-01-11

Issue

Section

History Matters